User talk:Rah175/Term Paper Proposal

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Student Comments

The format of this proposal need to be fixed. Two "Enter" or "br /" at the end of "Robert Herd EBME 300 3/7/2017 Term Paper Proposal"
"because of it is overly simple " remove "of"
" The variable I represents the external current injected in dc-current to the neuron." this sentence is a little bit confusing. Fix: " The variable, I, represents the external current injected in dc-current to the neuron." --Dominic Chen (talk) 18:03, 8 March 2017 (EST)

1. Work on the format: make sure to double enter in between paragraphs. Split up into the three paragraphs as well as separating the name, class, date, and title. Italicize the title of the paper too.

2. “The paper focuses on the creating large-scale…” should be “focuses on creating large-scale”

3. “Somewhat mutually exclusive” is awkward phrasing and a bit confusing

4. “This model appears to be the better choice over others like the integrate-and-fire model because of it is overly simple…” should be “because it is overly simple”

5. “Using bifurcation theories, the paper hypothesizes that, a simple spiking model can be presented that is as biologically authentic as the Hodgkin-Huxley model all while being computationally expressive as an integrate-and-fire model.”-awkwardly phrased

--Lexi Meglio (talk) 21:41, 8 March 2017 (EST)

Instructor Comments

This is a very poor proposal.

"This model appears to be the better choice over others like the integrate-and-fire model because of it is overly simple and doesn’t produce an authentic spiking dynamic and burst dynamic from the cortical neurons." -- Unfortunately, this sentence does not make sense and suggests you did not proofread carefully.

Your hypothesis seems to make little sense, and it may not be very different from "It is possible to model...", which is not really a falsifiable hypothesis. We recommend you devise your own falsifiable hypothesis that can be tested with the model.

Your model reproduction for this course will be in Mathematica, not MATLAB.

The two-dimensional model described in your paper is not the Hodgkin-Huxley model. Rather, the model in this paper is a simplification of that classic model. Please note that the full Hodgkin-Huxley model was presented in Chapter 7 of the textbook. We encourage you to familiarize yourself with it.

"v′=u′=" -- I am sure this must be a mistake.

Your descriptions of the parameters are identical or almost identical to the paper's. Please review the policy page here.

"I will use these values and the matlab code given..." -- You cannot use the MATLAB code provided with the paper as your model reconstruction. You may use it as a guide, but your reconstruction will be done in Mathematica.

You use the term "polarized" many times. You probably mean "depolarized" or "hyperpolarized", which generally refer to excitation and inhibition of a neuron, respectively. Please see Chapter 7 in which these terms are defined and described in detail.

"My results should show that the injected current helps to polarize a cortical neuron faster than one that only has potassium and sodium ions present." -- This does not make a lot of sense, and it appears to be describing a trivial feature of the model.

"I will focus on solving equations (1) and (2)." -- What do you mean? These equations are the model itself. They cannot be solved individually using, for example, DSolve, since they constitute a coupled system of equations. Furthermore, since Eq. 3 introduces a non-linear reset, it is not very likely that there exists a closed form analytical solution.

"Other extensions of the model that can be explored could be whether an imbalance of sodium and potassium ions affect the ability for a cortical neuron to produce an action potential." -- This would be a nice thing to test in a more detailed model, but this model does not provide the "knobs" necessary to make these changes. What are you proposing?

You should insert blank lines between lines that you would like to be followed with a line break, such as your name.

--Jeffrey Gill (talk) 16:36, 13 March 2017 (EDT)